Biotechnology

Definition

Biotechnology is the use of biological processes, organisms, or systems to manufacture products intended to improve the quality of human life.

History

Biotechnology is not a new field.It was dated back in ancient times.In ancient times biotechnology is used in brewing industry,in making of cheese and yogurt  and for the preservation of different things.

For thousands of years, humans have used selective breeding to improve production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops.

In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917,. Chaim Weizmann first used a pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum, to produce acetone, which the United Kingdom desperately needed to manufacture explosives during World War I.

Biotechnology has also led to the development of antibiotics. In 1928.

The field of modern biotechnology is thought to have largely begun on June 16, 1980.

Types

Biotechnology has mainly 4 fields or types that are

  • Red Biotechnology

                  It is also known as medicinal biotechnology.

This includes genome, proteome, and metabolic studies, etc., to provide knowledge of the  relationship between molecular biology and illnesses, increasing the possibility of finding new therapeutic solutions. Modern (bio)technologies have an impact in the validation phase of the solutions found, for example through the use of genetically modified animals. Nanotechnology applications can help develop more effective methods for product delivery.

This actually leads to:

– finding more effective solutions with respect to those based on traditional methods, as well as therapeutic solutions for illnesses and problems never solved before, including cures for rare illnesses;

– a reduction in the times required for medicine development, which are extremely long using traditional methods.

The main applications are:

  1. (bio)medicine: macromolecules; biosimilar products (meaning medicines containing the same biomolecules as medicines that are no longer covered by patents); molecules of medium-small dimensions;
  2. innovative therapeutic techniques: cell therapies, based also on stem cells; genetic therapies; therapies based on antisense and RNA interference; xenotransplants (production of genetically modified animals to supply organs for transplants);
  3. vaccines, both preventive and therapeutic;
  4. diagnostics, mainly using techniques based on proteins and nucleic acids (DNA/RNA).
  • Green Biotechnology

                    It is known as agricultural biotechnology.Green biotechnology concerns the primary sector (agriculture and zootechnical sectors) and the   activities associated with the  food chain.

Applications of Green biotechnology are

  1. diagnostic control in the food chain. The objectives are: foodstuff safety (e.g. for the identification of pathogens such as salmonella) and food tractability (particularly important when using genetically modified organisms).
  2. the use of additives in feed, mainly enzymes, amino acids and vitamins. These additives are used to increase and improve animal growth, reduce nutrition costs and environmental impact, etc.
  • White Biotechnology

                     It is also known as industrial biotechnology.

Industrial biotechnology is the application of biotechnology for industrial purposes, including manufacturing, alternative energy (or “bioenergy”), and biomaterials. It includes the practice of using cells or components of cells like enzymes to generate industrially useful products.

There is a wide variety of sectors of application:

  1.   pharmaceutical sector
  2.  cosmetic and cosmeceutical products
  3.  agro-industrial sector and animal feed;
  4.  textile and leather products sector;
  5.   paper industry;
  6.  mining sector, for mining minerals (copper, zinc, cobalt, etc.);
  7.  chemical products (antibiotics, vitamins, biopolymers, enzymes, amino acids, etc.).
  8. In the detergents sector, biotechnologies are not actually used in the production process but rather in the composition of the finished product, adding enzymes to improve its characteristics.
  9. An important industrial application of biotechnologies is the production of biofuels.
  • Blue Biotechnology

                  It is also known as marine biotechnology.

Blue biotechnology is a term that has been used to describe the marine and aquatic applications of biotechnology.It mainly concerned with oceans,river and marine life.

 

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Bioinformatics

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Basic Definition:

Bioinformatics is the application of computer science and information technology to the field of biology and medicine.

Detailed Definition:

Bioinformatics is computerizing biology in terms of molecules( in sense of physical chemistry) and then applying informatics techniques(derived from disciplines of applied mathematics and statistics) to understand and organize information associated with these molecules on large scale.

Bioinformatics:

It basically deals with

  • Algorithms
  • Databases
  • Web technologies
  • Soft computing
  • Information and computational theory
  • Nucleotide sequences(DNA & RNA)
  • Protein sequences

Programming languages that use in bioinformatics are Java,XML,Perl,C,C++ etc.

Main goals of bioinformatics are

  1. Drug designing
  2. Gene finding
  3. Genome alignment
  4. Protein alignment
  5. Gene expression
  6. Protein protein interaction

Major areas of Research in Bioinformatics are

  1. Sequence analysis
  2. Genome annotation
  3. Computational evolutionary biology
  4. Literature analysis
  5. Analysis of gene expression
  6. Analysis of protein expression
  7. Analysis of mutation in cancer
  8. Comparative genomics
  9. Modeling biological system
  10. High-throughput image analysis

Different database are used to perform different functions by using specific bioinformatics tools.List of some important databases is given below

  1. NCBI (National Center for biotechnology information)
  2. EBI (European bioinformatics institute)
  3. DDBJ (DNA Databank of Japan)
  4. PDB    (Protein databank)
  5. OMIM (Online Mandalian Inheritance of Man)
  6. Swiss Prot/Uni Prot
  7. MMDB (Molecular Modeling Databank)

and many more.

Applications of bioinformatics:

  • Molecular medicine
  • Personalised medicine
  • Preventative medicine
  • Gene therapy
  • Drug development
  • Microbial genome applications
  • Waste cleanup
  • Climate change Studies
  • Alternative energy sources
  • Biotechnology
  • Antibiotic resistance
  • Forensic analysis of microbes
  • Bio-weapon creation
  • Evolutionary studies
  • Crop improvement
  • Insect resistance
  • Improve nutritional quality
  • Development of Drought resistance varieties
  • Vetinary Science
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